{"id":248,"date":"2012-03-01T14:16:08","date_gmt":"2012-03-01T14:16:08","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=248"},"modified":"2024-01-08T10:06:22","modified_gmt":"2024-01-08T10:06:22","slug":"sumo-modification-of-the-neuroprotective-protein-tdp1-facilitates-chromosomal-single-strand-break-repair","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/sumo-modification-of-the-neuroprotective-protein-tdp1-facilitates-chromosomal-single-strand-break-repair\/","title":{"rendered":"\u062a\u0639\u062f\u064a\u0644 SUMO \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u062d\u0645\u064a \u0644\u0644\u0623\u0639\u0635\u0627\u0628 TDP1 \u064a\u0633\u0647\u0644 \u0625\u0635\u0644\u0627\u062d \u0643\u0633\u0631 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u0645\u0641\u0631\u062f\u0629"},"content":{"rendered":"

\u064a\u0639\u062f \u0643\u0633\u0631 \u0648\u0625\u063a\u0644\u0627\u0642 \u0634\u0631\u064a\u0637 \u0648\u0627\u062d\u062f \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0633\u0645\u0629 \u0645\u062a\u0623\u0635\u0644\u0629 \u0641\u064a \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 \u0644\u0644\u062a\u063a\u0644\u0628 \u0639\u0644\u0649 \u0627\u0644\u062d\u0648\u0627\u062c\u0632 \u0627\u0644\u0627\u0644\u062a\u0648\u0627\u0626\u064a\u0629. \u064a\u0624\u062f\u064a \u0627\u0644\u0641\u0634\u0644 \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u0625\u063a\u0644\u0627\u0642 \u062e\u064a\u0648\u0637 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0643\u0633\u0648\u0631\u0629 \u0625\u0644\u0649 \u0643\u0633\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u0633\u0628\u0628 \u062a\u0646\u0643\u0633\u064b\u0627 \u0639\u0635\u0628\u064a\u064b\u0627 \u0644\u062f\u0649 \u0627\u0644\u0628\u0634\u0631. \u064a\u062a\u062c\u0644\u0649 \u0630\u0644\u0643 \u0641\u064a \u0648\u062c\u0648\u062f \u0639\u064a\u0648\u0628 \u0641\u064a \u0625\u0646\u0632\u064a\u0645 Tyrosyl DNA phosphodiesterase 1 (TDP1)\u060c \u0627\u0644\u0630\u064a \u064a\u0632\u064a\u0644 \u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 1 \u0627\u0644\u0645\u062a\u0648\u0642\u0641\u0629 \u0645\u0646 \u0637\u0631\u0641 DNA. \u0646\u0648\u0636\u062d \u0647\u0646\u0627 \u0623\u0646 TDP1 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0631\u0643\u064a\u0632\u0629 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0639\u062f\u064a\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u064f\u0639\u062f\u0650\u0651\u0644 \u0627\u0644\u0635\u063a\u064a\u0631 \u0627\u0644\u0634\u0628\u064a\u0647 \u0628\u0627\u0644\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 SUMO. \u0646\u0642\u0648\u0645 \u0628\u062a\u0646\u0642\u064a\u0629 SUMOylation TDP1 \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062b\u062f\u064a\u064a\u0627\u062a \u0648\u0646\u062d\u062f\u062f \u0645\u0648\u0642\u0639 SUMOylation \u0628\u0627\u0633\u0645 \u0644\u064a\u0633\u064a\u0646 111. \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 SUMOylation \u0644\u0627 \u064a\u064f\u0638\u0647\u0631 \u0623\u064a \u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u062a\u062d\u0641\u064a\u0632\u064a \u0644\u0640 TDP1\u060c \u0641\u0625\u0646\u0647 \u064a\u0639\u0632\u0632 \u062a\u0631\u0627\u0643\u0645\u0647 \u0641\u064a \u0645\u0648\u0627\u0642\u0639 \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u064a\u0639\u0631\u0636 \u0627\u0644\u0645\u062a\u062d\u0648\u0644 \u0627\u0644\u0646\u0627\u0642\u0635 \u0641\u064a TDP1 SUMOylation \u0645\u0639\u062f\u0644\u064b\u0627 \u0645\u0646\u062e\u0641\u0636\u064b\u0627 \u0644\u0625\u0635\u0644\u0627\u062d \u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u0645\u0641\u0631\u062f\u0629 \u0627\u0644\u0646\u0627\u0634\u0626\u0629 \u0639\u0646 \u0646\u0634\u0627\u0637 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 1 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0646\u0633\u062e \u0623\u0648 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a. \u062a\u062d\u062f\u062f \u0647\u0630\u0647 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u062f\u0648\u0631 SUMO \u0623\u062b\u0646\u0627\u0621 \u0625\u0635\u0644\u0627\u062d \u0627\u0644\u0643\u0633\u0631 \u0627\u0644\u0645\u0641\u0631\u062f\u060c \u0648\u062a\u0642\u062a\u0631\u062d \u0622\u0644\u064a\u0629 \u0644\u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0645\u0646 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0633\u0645\u064a \u0627\u0644\u062c\u064a\u0646\u064a.<\/p>\n\n\n\n

\u0647\u062f\u0633\u0648\u0646\u060c \u062c\u064a\u0647 \u0622\u0631\u060c \u062a\u0634\u064a\u0627\u0646\u062c\u060c \u0625\u0633\u060c \u0648\u064a\u0644\u0632\u060c \u0623\u0648 \u0625\u0633\u060c \u0631\u0648\u0643\u064a\u0627\u0631\u062f\u060c \u0633\u064a\u060c \u0625\u0644-\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong>\u060c \u0633\u0627\u062f\u0633 (2012). \u062a\u0639\u062f\u064a\u0644 SUMO \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u062d\u0645\u064a \u0644\u0644\u0623\u0639\u0635\u0627\u0628 TDP1 \u064a\u0633\u0647\u0644 \u0625\u0635\u0644\u0627\u062d \u0643\u0633\u0631 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u0645\u0641\u0631\u062f\u0629<\/a>. \u0646\u064a\u062a\u0634\u0631 \u0643\u0648\u0645\u064a\u0648\u0646\u064a\u0643\u064a\u0634\u0646\u0632\u060c 13\u061b 3:733<\/p>","protected":false},"excerpt":{"rendered":"

Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1), which removes stalled topoisomerase 1 peptides from DNA termini. Here we […]<\/p>\n","protected":false},"author":8,"featured_media":388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[18,61,95],"class_list":{"0":"post-248","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-18","10":"tag-health","11":"tag-research"},"yoast_head":"\nSUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/sumo-modification-of-the-neuroprotective-protein-tdp1-facilitates-chromosomal-single-strand-break-repair\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair - Menarah\" \/>\n<meta property=\"og:description\" content=\"Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1), which removes stalled topoisomerase 1 peptides from DNA termini. 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