{"id":243,"date":"2013-12-01T13:55:34","date_gmt":"2013-12-01T13:55:34","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=243"},"modified":"2024-01-08T10:05:09","modified_gmt":"2024-01-08T10:05:09","slug":"tdp1-deficiency-sensitizes-human-cells-to-base-damage-via-distinct-topoisomerase-i-and-parp-mechanisms-with-potential-applications-for-cancer-therapy","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/tdp1-deficiency-sensitizes-human-cells-to-base-damage-via-distinct-topoisomerase-i-and-parp-mechanisms-with-potential-applications-for-cancer-therapy\/","title":{"rendered":"\u064a\u0624\u062f\u064a \u0646\u0642\u0635 TDP1 \u0625\u0644\u0649 \u062a\u062d\u0633\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0644\u0644\u0636\u0631\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0639\u0628\u0631 \u0622\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 I \u0648 PARP \u0627\u0644\u0645\u062a\u0645\u064a\u0632\u0629 \u0645\u0639 \u0627\u0644\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0631\u0637\u0627\u0646"},"content":{"rendered":"

\u064a\u0639\u062f \u0627\u0644\u0636\u0631\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0648\u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 I (Top1) \u0645\u0646 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0648\u0641\u064a\u0631\u0629 \u0644\u0643\u0633\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062f\u0627\u062e\u0644\u064a\u060c \u0645\u0645\u0627 \u064a\u0633\u0627\u0647\u0645 \u0641\u064a \u0627\u0644\u0631\u0646\u062d \u0627\u0644\u0648\u0631\u0627\u062b\u064a \u0648\u064a\u0633\u0628\u0628 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646. \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u062a\u0643\u0631\u0627\u0631\u0647\u0627\u060c \u0641\u0625\u0646 \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0639\u0644\u0649 \u0625\u0635\u0644\u0627\u062d \u0647\u0630\u0647 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0645\u0646 \u062a\u0643\u0633\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641\u0629 \u0625\u0644\u0649 \u062d\u062f \u0643\u0628\u064a\u0631. \u0647\u0646\u0627 \u060c \u0646\u0630\u0643\u0631 \u0623\u0646 \u0627\u0633\u062a\u0646\u0641\u0627\u062f Tyrosyl DNA phosphodiesterase 1 (TDP1) \u064a\u062d\u0633\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0644\u062a\u0644\u0641 \u0627\u0644\u0623\u0644\u0643\u0644\u0629 \u0648\u0623\u0646 \u0627\u0644\u0627\u0633\u062a\u0646\u0641\u0627\u062f \u0627\u0644\u0625\u0636\u0627\u0641\u064a \u0644\u0644\u0646\u0648\u0643\u0644\u064a\u0627\u0632 \u0627\u0644\u062f\u0627\u062e\u0644\u064a \u0627\u0644\u0623\u0628\u0648\u0631\u064a\u0646\u064a\u0643 \/ \u0627\u0644\u0623\u0628\u064a\u0631\u064a\u0645\u064a\u062f\u064a\u0646 I (APE1) \u064a\u0645\u0646\u062d \u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0623\u0639\u0644\u0649 \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u0644\u0648\u062d\u0638\u062a \u0641\u064a \u0627\u0633\u062a\u0646\u0641\u0627\u062f TDP1 \u0623\u0648 APE1 \u0648\u062d\u062f\u0647. \u064a\u0624\u0643\u062f \u0627\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0643\u0645\u064a \u0644\u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0648\u0641\u062d\u0648\u0635\u0627\u062a \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u062f\u0648\u0631 TDP1 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0636\u0631\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u060c \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u0642\u0644 \u0639\u0646 APE1. \u062a\u062a\u0645 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0623\u0644\u0643\u0644\u0629 \u062c\u0632\u0626\u064a\u064b\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0633\u062a\u0646\u0641\u0627\u062f Top1\u060c \u0645\u0645\u0627 \u064a\u0648\u0636\u062d \u0623\u0646 \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0623\u0644\u0643\u0644\u0629 \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u0641\u0648\u0627\u0635\u0644 Top1 \u0627\u0644\u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u062a\u062b\u0628\u064a\u0637 \u0646\u0634\u0627\u0637 PARP \u0644\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0648\u0639\u064a\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0639\u0627\u0646\u064a \u0645\u0646 \u0646\u0642\u0635 TDP1 \u062a\u062c\u0627\u0647 \u0633\u0645\u0648\u0645 Top1\u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u064a\u0645\u0646\u062d \u062d\u0633\u0627\u0633\u064a\u0629 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 \u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0623\u0644\u0643\u0644\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0644\u0637 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u0627\u0644\u0623\u062f\u0648\u0627\u0631 \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644\u0629 \u062c\u0632\u0626\u064a\u064b\u0627 \u0644\u0640 PARP \u0648TDP1 \u0627\u0633\u062a\u062c\u0627\u0628\u0629\u064b \u0644\u0644\u062a\u062d\u062f\u064a \u0627\u0644\u0633\u0645\u064a \u0627\u0644\u062c\u064a\u0646\u064a. \u0623\u062e\u064a\u0631\u064b\u0627\u060c \u0623\u062b\u0628\u062a\u0646\u0627 \u0623\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0643\u0648\u0646 \u0641\u064a\u0647\u0627 TDP1 \u0646\u0627\u0642\u0635\u064b\u0627 \u0628\u0637\u0628\u064a\u0639\u062a\u0647\u0627 \u062a\u0643\u0648\u0646 \u0634\u062f\u064a\u062f\u0629 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0623\u0644\u0643\u0644\u0629 \u0648\u0623\u0646 \u0627\u0633\u062a\u0646\u0641\u0627\u062f TDP1 \u064a\u062d\u0633\u0651\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0648\u0631\u0645 \u0627\u0644\u0623\u0631\u0648\u0645\u064a \u0627\u0644\u062f\u0628\u0642\u064a \u062a\u062c\u0627\u0647 \u0639\u0627\u0645\u0644 \u0627\u0644\u0623\u0644\u0643\u0644\u0629 \u062a\u064a\u0645\u0648\u0632\u0648\u0644\u0648\u0645\u064a\u062f.<\/p>\n\n\n\n

\u0623\u0644\u0627\u062c\u0648\u0632 \u0625\u0645\u060c \u0648\u064a\u0644\u0632 \u0623\u0648 \u0625\u0633\u060c \u0625\u0644-\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633\u0627\u062f\u0633 (2013). \u064a\u0624\u062f\u064a \u0646\u0642\u0635 TDP1 \u0625\u0644\u0649 \u062a\u062d\u0633\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0644\u0644\u0636\u0631\u0631 \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0645\u0646 \u062e\u0644\u0627\u0644 \u0622\u0644\u064a\u0627\u062a TOP1 \u0648PARP \u0627\u0644\u0645\u062a\u0645\u064a\u0632\u0629 \u0645\u0639 \u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0631\u0637\u0627\u0646<\/a>. \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0627\u0644\u062f\u0642\u0629 1\u061b 42(5): 3089-103.<\/p>","protected":false},"excerpt":{"rendered":"

Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents. Despite their frequency, the overlapping mechanisms that repair these forms of DNA breakage are largely unknown. Here, we report that depletion of Tyrosyl DNA phosphodiesterase […]<\/p>\n","protected":false},"author":8,"featured_media":473,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[19,61,95],"class_list":{"0":"post-243","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-19","10":"tag-health","11":"tag-research"},"yoast_head":"\nTDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/tdp1-deficiency-sensitizes-human-cells-to-base-damage-via-distinct-topoisomerase-i-and-parp-mechanisms-with-potential-applications-for-cancer-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy - Menarah\" \/>\n<meta property=\"og:description\" content=\"Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents. 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