{"id":233,"date":"2015-03-26T11:59:33","date_gmt":"2015-03-26T11:59:33","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=233"},"modified":"2024-01-08T10:03:15","modified_gmt":"2024-01-08T10:03:15","slug":"piericidin-a-aggravates-tau-pathology-in-p301s-transgenic-mice","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/piericidin-a-aggravates-tau-pathology-in-p301s-transgenic-mice\/","title":{"rendered":"\u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0641\u0627\u0642\u0645 \u0623\u0645\u0631\u0627\u0636 \u062a\u0627\u0648 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u0627 P301S"},"content":{"rendered":"

\u0645\u0648\u0636\u0648\u0639\u064a<\/h3>\n\n\n\n

\u062a\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 P301S \u0641\u064a \u0625\u0643\u0633\u0648\u0646 10 \u0645\u0646 \u062c\u064a\u0646 \u062a\u0627\u0648 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a \u0627\u0644\u0648\u0631\u0627\u062b\u064a. \u0641\u064a \u062d\u064a\u0646 \u062a\u0645 \u0631\u0628\u0637 \u062a\u062b\u0628\u064a\u0637 \u0645\u0631\u0643\u0628 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 I \u0628\u0627\u0639\u062a\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u0648\u0648\u0628\u0627 \u0627\u0644\u0645\u062a\u0641\u0631\u0642\u0629. \u0627\u0644\u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u0647\u0648 \u0639\u0636\u0648 \u0646\u0645\u0648\u0630\u062c\u064a \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646\u0627\u062a\u060c \u0648\u0647\u064a \u0641\u0626\u0629 \u0645\u0646 \u0645\u062b\u0628\u0637\u0627\u062a \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0627\u0644\u0646\u0634\u0637 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u064b\u0627\u060c \u0645\u0639\u0632\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u0639\u0642\u062f\u064a\u0629 \u0627\u0644\u0646\u064a\u0627\u0628\u0629.<\/em> \u0645\u0639 \u0627\u0644\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u0639\u0627\u0644\u0645\u064a \u0641\u064a \u0627\u0644\u0645\u0648\u0627\u0626\u0644 \u0627\u0644\u0628\u062d\u0631\u064a\u0629 \u0648\u0627\u0644\u0632\u0631\u0627\u0639\u064a\u0629. \u0643\u0627\u0646 \u0627\u0644\u0647\u062f\u0641 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0647\u0648 \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u062a\u0641\u0627\u0639\u0644 \u0645\u0645\u0631\u0636 \u0628\u064a\u0646 \u0627\u0644\u0633\u0645 \u0627\u0644\u0628\u064a\u0626\u064a \u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u0648\u0637\u0641\u0631\u0629 P301S.<\/p>\n\n\n\n

\u0637\u064f\u0631\u0642<\/h3>\n\n\n\n

\u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0639\u0628\u0631 \u0639\u0646 \u062a\u0627\u0648 \u0627\u0644\u0628\u0634\u0631\u064a \u0645\u0639 \u0637\u0641\u0631\u0629 P301S (P301S+\/+<\/sup>) \u0648\u062a\u0645 \u0639\u0644\u0627\u062c \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a \u0639\u0646\u062f \u0639\u0645\u0631 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u062a\u062d\u062a \u0627\u0644\u062c\u0644\u062f \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0631\u0643\u0628\u0629 (N = 10 P301S+\/+<\/sup>\u060c N = 7 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a) \u0623\u0648 \u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A (N = 9 P301S+\/+<\/sup>\u060c N = 9 \u0641\u0626\u0631\u0627\u0646 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a) \u0628\u062c\u0631\u0639\u0629 0.5 \u0645\u0644\u063a\u0645 \/ \u0643\u063a\u0645 \/ \u064a\u0648\u0645 \u0644\u0645\u062f\u0629 28 \u064a\u0648\u0645\u064b\u0627 \u0639\u0628\u0631 \u0627\u0644\u0645\u0636\u062e\u0627\u062a \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u0627\u0633\u0645\u0648\u0632\u064a\u0629. \u062a\u0645 \u0642\u064a\u0627\u0633 \u0623\u0645\u0631\u0627\u0636 \u062a\u0627\u0648 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062a\u0639\u062f\u0627\u062f \u0627\u0644\u0645\u062c\u0633\u0645 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0636\u062f \u062a\u0627\u0648 \u0627\u0644\u0645\u0641\u0633\u0641\u0631 (AD2\u060c AT8\u060c AT180\u060c \u0648AT100) \u0648\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0644\u0637\u062e\u0629 \u0627\u0644\u063a\u0631\u0628\u064a\u0629 \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u0629.<\/p>\n\n\n\n

\u0646\u062a\u0627\u0626\u062c<\/h3>\n\n\n\n

\u0632\u0627\u062f \u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0645\u0646 \u0639\u062f\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0641\u0648\u0633\u0641\u0648 \u062a\u0627\u0648 \u0641\u064a \u0627\u0644\u0642\u0634\u0631\u0629 \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629 \u0641\u064a P301S+\/+<\/sup> \u0627\u0644\u0641\u0626\u0631\u0627\u0646\u060c \u0648\u0644\u0643\u0646 \u0628\u062f\u0631\u062c\u0629 \u0645\u062a\u0641\u0627\u0648\u062a\u0629 \u0648\u0645\u0639\u062a\u062f\u0644\u0629 \u0641\u0642\u0637 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u062f\u0649 \u0627\u0644\u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u062a\u0627\u0648 \u0627\u0644\u0645\u0641\u0633\u0641\u0631 \u0628\u0634\u0643\u0644 \u0645\u0631\u0636\u064a \u0641\u0642\u0637 \u0641\u064a P301S+\/+<\/sup> \u0627\u0644\u0641\u0626\u0631\u0627\u0646. \u0641\u064a \u062d\u064a\u0646 \u0623\u0646\u0646\u0627 \u0644\u0645 \u0646\u0644\u0627\u062d\u0638 \u0623\u064a \u0641\u0642\u062f\u0627\u0646 \u0648\u0627\u0636\u062d \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0641\u064a \u0627\u0644\u0642\u0634\u0631\u0629 \u0627\u0644\u0623\u0645\u0627\u0645\u064a\u0629\u060c \u0641\u0642\u062f \u0627\u0646\u062e\u0641\u0636\u062a \u0643\u062b\u0627\u0641\u0629 \u0627\u0644\u062a\u0634\u0627\u0628\u0643 \u0627\u0644\u0639\u0635\u0628\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0639\u0644\u0627\u062c \u0627\u0644\u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u0641\u064a P301S.+\/+<\/sup> \u0627\u0644\u0641\u0626\u0631\u0627\u0646.<\/p>\n\n\n\n

\u0645\u0646\u0627\u0642\u0634\u0629<\/h3>\n\n\n\n

\u062a\u0648\u0636\u062d \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0641\u0627\u0642\u0645 \u0645\u0633\u0627\u0631 \u0623\u0645\u0631\u0627\u0636 \u062a\u0627\u0648 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0648\u0631\u0627\u062b\u064a\u064b\u0627\u060c \u0645\u0645\u0627 \u064a\u0648\u0641\u0631 \u062f\u0639\u0645\u064b\u0627 \u062a\u062c\u0631\u064a\u0628\u064a\u064b\u0627 \u0644\u0645\u0641\u0647\u0648\u0645 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0628\u064a\u0626\u0629 \u0641\u064a \u0645\u0633\u0628\u0628\u0627\u062a \u0623\u0645\u0631\u0627\u0636 \u062a\u0627\u0648.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u0645\u0627\u062a\u064a\u0627\u0633 \u0647\u0648\u0644\u0631\u0647\u0627\u062c\u060c \u0631\u0648\u0645\u0627\u0646 \u062f\u064a\u0643\u060c \u0623\u0646\u062f\u0631\u0633\u0648\u0646 \u062f\u064a \u0623\u0646\u062f\u0631\u0627\u062f\u064a\u060c \u062c\u064a\u0633\u064a\u0646 \u0631\u064a\u0633\u0628\u0648\u0646\u062f\u064a\u0643\u060c \u0647\u0648\u0646\u063a \u0634\u0648\u060c \u062a\u0648\u0645\u0627\u0633 \u062f\u0628\u0644\u064a\u0648 \u0631\u0648\u0633\u0644\u0631\u060c \u0645\u062d\u0645\u062f \u0633\u0644\u0627\u0645\u0629<\/strong>\u060c \u062a\u0648\u0645\u0627\u0633 \u0643\u0627\u0631\u0644\u0633\u0648\u0646\u060c \u0625\u0644\u064a\u0632\u0627\u0628\u064a\u062b \u0633. \u064a\u0627\u0645\u0627\u062f\u0627\u060c \u0633\u0647\u0627\u0645 \u0623. \u062c\u0627\u062f \u0627\u0644\u062d\u0642\u060c \u0645\u064a\u0634\u064a\u0644 \u062c\u0648\u062f\u064a\u0631\u062a\u060c \u0641\u0648\u0644\u0641\u063a\u0627\u0646\u063a \u0625\u062a\u0634 \u0623\u0648\u0631\u062a\u0644\u060c \u063a\u0648\u0646\u062a\u0631 \u064a\u0648 \u0647\u0648\u063a\u0644\u064a\u0646\u063a\u0631. 2015. \u0628\u064a\u0631\u064a\u0633\u064a\u062f\u064a\u0646 A \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0641\u0627\u0642\u0645 \u0623\u0645\u0631\u0627\u0636 \u062a\u0627\u0648 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u0627 P301S.<\/a> \u0628\u0644\u0648\u0633 \u0648\u0627\u062d\u062f 9(12):e113557.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u0645\u0635\u062f\u0631 \u0627\u0644\u0635\u0648\u0631\u0629: \u0644\u0648\u064a\u0633 \u0631\u064a\u062f\u060c unsplash.com<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Objective The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyces spp. with global distribution in marine and […]<\/p>\n","protected":false},"author":13,"featured_media":868,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[21,61,95],"class_list":{"0":"post-233","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-21","10":"tag-health","11":"tag-research"},"yoast_head":"\nPiericidin A Aggravates Tau Pathology in P301S Transgenic Mice - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/piericidin-a-aggravates-tau-pathology-in-p301s-transgenic-mice\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice - Menarah\" \/>\n<meta property=\"og:description\" content=\"Objective The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. 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