{"id":232,"date":"2015-02-01T11:57:42","date_gmt":"2015-02-01T11:57:42","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=232"},"modified":"2024-01-08T10:03:49","modified_gmt":"2024-01-08T10:03:49","slug":"clinical-and-cellular-roles-for-tdp1-and-top1-in-modulating-colorectal-cancer-response-to-irinotecan","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/clinical-and-cellular-roles-for-tdp1-and-top1-in-modulating-colorectal-cancer-response-to-irinotecan\/","title":{"rendered":"\u0627\u0644\u0623\u062f\u0648\u0627\u0631 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0644\u0640 TDP1 \u0648TOP1 \u0641\u064a \u062a\u0639\u062f\u064a\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0644\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646"},"content":{"rendered":"<p>\u064a\u0639\u062f \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u062b\u0627\u0644\u062b \u0623\u0643\u062b\u0631 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0634\u064a\u0648\u0639\u064b\u0627 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0644\u062c\u0631\u0627\u062d\u0629\u060c \u0641\u0625\u0646 \u0645\u0627 \u064a\u0635\u0644 \u0625\u0644\u0649 50% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u064a\u0646\u062a\u0643\u0633\u0648\u0646 \u0628\u0633\u0628\u0628 \u0645\u0631\u0636 \u063a\u064a\u0631 \u0642\u0627\u0628\u0644 \u0644\u0644\u0634\u0641\u0627\u0621. \u064a\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0641\u064a \u0627\u0644\u062e\u0637 \u0627\u0644\u0623\u0648\u0644 \u0645\u0627\u062f\u0629 \u062a\u0648\u0628\u0648\u064a\u0633\u0648\u0645\u064a\u0631\u0627\u0632 1 (TOP1) \u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646 \u0627\u0644\u0633\u0627\u0645\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u062d\u0627\u0635\u0631\u0629 TOP1 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u062a\u062a\u0645 \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u0628\u0628\u062a\u064a\u062f TOP1 \u0645\u0646 \u0641\u0648\u0627\u0635\u0644 TOP1-DNA \u0628\u0648\u0627\u0633\u0637\u0629 tyrosyl-DNA phosphodiesterase 1 (TDP1). \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u0627\u0631 \u0627\u0644\u0645\u0641\u062a\u0631\u0636\u0629 \u0644\u0640 TDP1 \u0648TOP1 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645\u060c \u0625\u0644\u0627 \u0623\u0646 \u062f\u0648\u0631\u0647\u0645\u0627 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 TOP1 \u0644\u0627 \u064a\u0632\u0627\u0644 \u063a\u064a\u0631 \u0648\u0627\u0636\u062d. \u0646\u0639\u0631\u0636 \u0647\u0646\u0627 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u062a\u0639\u0628\u064a\u0631 \u0645\u062a\u0641\u0627\u0648\u062a\u0629 \u0644\u0644\u0628\u0648\u0644\u064a \u0628\u0628\u062a\u064a\u062f\u0627\u062a TOP1 \u0648TDP1 \u0641\u064a \u062e\u0637\u0648\u0637 \u062e\u0644\u0627\u064a\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0648\u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629. \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 TDP1 \u0623\u0648 \u0627\u0633\u062a\u0646\u0641\u0627\u062f TOP1 \u0623\u0645\u0631\u064b\u0627 \u0648\u0642\u0627\u0626\u064a\u064b\u0627. \u0639\u0644\u0649 \u0627\u0644\u0639\u0643\u0633 \u0645\u0646 \u0630\u0644\u0643\u060c \u064a\u0624\u062f\u064a \u0627\u0633\u062a\u0646\u0641\u0627\u062f TDP1 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u062a\u0643\u0633\u0631 \u062d\u0628\u0644\u0627 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0648\u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646 \u0628\u0637\u0631\u064a\u0642\u0629 \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 TOP1\u060c \u0645\u0645\u0627 \u064a\u0648\u0641\u0631 \u0641\u0631\u0635\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645. \u062a\u0631\u062a\u0628\u0637 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 TDP1 \u0628\u0634\u0643\u0644 \u062c\u064a\u062f \u0645\u0639 mRNA \u0648\u0645\u0639 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u062a\u062d\u0641\u064a\u0632\u064a TDP1. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0644\u0645 \u064a\u0644\u0627\u062d\u0638 \u0623\u064a \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a TDP1 \u0623\u0648 TOP1 \u0627\u0644\u0645\u062a\u0623\u0635\u0644\u0629 \u0648\u062d\u062f\u0647\u0627 \u0648\u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646\u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0641\u0627\u0626\u062f\u062a\u0647\u0627 \u0627\u0644\u0645\u062d\u062f\u0648\u062f\u0629 \u0643\u0645\u0624\u0634\u0631\u0627\u062a \u062d\u064a\u0648\u064a\u0629 \u062a\u0646\u0628\u0624\u064a\u0629 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645. \u062a\u062d\u062f\u062f \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c TDP1 \u0643\u0647\u062f\u0641 \u0639\u0644\u0627\u062c\u064a \u0645\u062d\u062a\u0645\u0644 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0648\u062a\u0634\u0643\u0643 \u0641\u064a \u0635\u062d\u0629 TOP1 \u0623\u0648 TDP1 \u0628\u0645\u0641\u0631\u062f\u0647\u0627 \u0643\u0645\u0624\u0634\u0631\u0627\u062a \u062d\u064a\u0648\u064a\u0629 \u062a\u0646\u0628\u0624\u064a\u0629 \u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646.&nbsp;<em>\u0645\u0648\u0644 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0647\u0646\u0627\u0643\u061b 14(2); 575-85. \u00a9 2014 \u0622\u0643\u0631<\/em>.<\/p>\n\n\n\n<p>Meisenberg C\u060c Gilbert DC\u060c Chalmers A\u060c Haley V\u060c Gollins S\u060c Ward SE\u060c El-<strong>\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633\u0627\u062f\u0633 (2015). <a href=\"https:\/\/mct.aacrjournals.org\/content\/14\/2\/575\">\u0627\u0644\u0623\u062f\u0648\u0627\u0631 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0640 TDP1 \u0648TOP1 \u0641\u064a \u062a\u0639\u062f\u064a\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0644\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646.<\/a> \u0645\u0648\u0644 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0647\u0646\u0627\u0643. 14(2): 575-85<\/p>","protected":false},"excerpt":{"rendered":"<p>Colorectal cancer is the third most common cancer in the world. Despite surgery, up to 50% of patients relapse with incurable disease. First-line chemotherapy uses the topoisomerase 1 (TOP1) poison irinotecan, which triggers cell death by trapping TOP1 on DNA. The removal of TOP1 peptide from TOP1\u2013DNA breaks is conducted by tyrosyl-DNA phosphodiesterase 1 (TDP1). [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":464,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[21,61,95],"class_list":{"0":"post-232","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-21","10":"tag-health","11":"tag-research"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/clinical-and-cellular-roles-for-tdp1-and-top1-in-modulating-colorectal-cancer-response-to-irinotecan\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan - Menarah\" \/>\n<meta property=\"og:description\" content=\"Colorectal cancer is the third most common cancer in the world. 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