{"id":226,"date":"2017-04-01T11:34:33","date_gmt":"2017-04-01T11:34:33","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=226"},"modified":"2024-01-08T09:57:33","modified_gmt":"2024-01-08T09:57:33","slug":"mitochondrial-protein-linked-dna-breaks-perturb-mitochondrial-gene-transcription-and-trigger-free-radical-induced-dna-damage","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/mitochondrial-protein-linked-dna-breaks-perturb-mitochondrial-gene-transcription-and-trigger-free-radical-induced-dna-damage\/","title":{"rendered":"\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u064a\u0643\u0633\u0631 \u0646\u0633\u062e \u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u0627\u0644\u0645\u0636\u0637\u0631\u0628\u0629 \u0648\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0627\u0644\u062c\u0630\u0648\u0631 \u0627\u0644\u062d\u0631\u0629"},"content":{"rendered":"

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\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0639\u064a\u0648\u0628 \u0641\u064a \u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u062b\u0644\u0627\u062b\u064a \u0627\u0644\u0623\u0637\u0631\u0627\u0641 Tyrosyl DNA phosphodiesterase 1 (TDP1) \u0648\u0627\u0644\u062a\u0646\u0643\u0633 \u0627\u0644\u0639\u0635\u0628\u064a \u0648\u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062d\u062b \u0627\u0644\u0633\u0627\u0645 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 (PDBs) \u0648\u0648\u0633\u064a\u0637 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0624\u0643\u0633\u062f \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a. \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0625\u0634\u0639\u0627\u0639\u064a. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646\u0646\u0627 \u0646\u0639\u0631\u0641 \u0627\u0644\u0643\u062b\u064a\u0631 \u0639\u0646 \u0625\u0635\u0644\u0627\u062d PDBs \u0641\u064a \u0627\u0644\u0646\u0648\u0627\u0629\u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u0644\u0627 \u064a\u064f\u0639\u0631\u0641 \u0633\u0648\u0649 \u0627\u0644\u0642\u0644\u064a\u0644 \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627. \u0646\u0643\u0634\u0641 \u0623\u0646 TDP1 \u064a\u062d\u0644 PDBs \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 (mtPDBs)\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0639\u0632\u064a\u0632 \u0646\u0633\u062e \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627. \u064a\u0624\u062f\u064a \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0633\u0627\u0645 \u0645\u0646 \u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 I (TOP1mt *)\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0648\u0644\u062f mtPDBs \u0627\u0644\u0645\u0641\u0631\u0637\u060c \u0625\u0644\u0649 \u062a\u0646\u0638\u064a\u0645 \u062a\u0639\u0648\u064a\u0636\u064a \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 TDP1 \u0644\u0646\u0633\u062e \u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627. \u0641\u064a \u063a\u064a\u0627\u0628 TDP1\u060c \u064a\u0624\u062f\u064a \u0639\u062f\u0645 \u0627\u0644\u062a\u0648\u0627\u0632\u0646 \u0641\u064a \u0646\u0633\u062e \u0627\u0644\u0648\u062d\u062f\u0627\u062a \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u0644\u0633\u0644\u0633\u0644\u0629 \u0646\u0642\u0644 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646 (ETC) \u0627\u0644\u0645\u0634\u0641\u0631\u0629 \u0628\u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u0648\u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0625\u0644\u0649 \u0633\u0648\u0621 \u062a\u062c\u0645\u064a\u0639 \u0645\u062c\u0645\u0639 ETC III. \u064a\u0643\u0634\u0641 \u062a\u062d\u062f\u064a\u062f \u0645\u0644\u0627\u0645\u062d \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0623\u064a\u0636\u064b\u0627 \u0623\u0646 TDP1 \u064a\u0639\u0632\u0632 \u0627\u0644\u0641\u0633\u0641\u0631\u0629 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0629 \u0641\u064a \u0638\u0644 \u0645\u062a\u0637\u0644\u0628\u0627\u062a \u0627\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0648\u0627\u0644\u0639\u0627\u0644\u064a\u0629. \u0648\u0645\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u0646 \u062e\u0644\u0644 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0633\u0631\u0628 \u0627\u0644\u062c\u0630\u0648\u0631 \u0627\u0644\u062d\u0631\u0629 \u0648\u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0646\u0648\u0648\u064a\u061b \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0644\u0645 \u064a\u062a\u0645 \u0628\u0639\u062f \u0627\u0644\u0643\u0634\u0641 \u0639\u0646 \u0648\u0633\u064a\u0637\u0629 \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u062c\u0630\u0631\u064a\u0629 \u0644\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c \u0623\u0628\u0644\u063a\u0646\u0627 \u0639\u0646 \u0632\u064a\u0627\u062f\u0629 \u062a\u0631\u0627\u0643\u0645 \u0627\u0644\u062c\u0630\u0648\u0631 \u0627\u0644\u0645\u062a\u0645\u0631\u0643\u0632\u0629 \u062d\u0648\u0644 \u0627\u0644\u0643\u0631\u0628\u0648\u0646 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0641\u062a\u0642\u0631 \u0625\u0644\u0649 TDP1\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a. \u0625\u0646 \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0625\u0646\u0632\u064a\u0645 \u0641\u0627\u0626\u0642 \u0623\u0643\u0633\u064a\u062f \u062f\u064a\u0633\u0645\u0648\u062a\u0627\u0632 1 (SOD1) \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0631\u0643\u0632 \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0628\u0648\u0646 \u0648\u064a\u062d\u0645\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0639\u0627\u0646\u064a \u0645\u0646 \u0646\u0642\u0635 TDP1 \u0645\u0646 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a. \u0639\u0644\u0649 \u0627\u0644\u0639\u0643\u0633 \u0645\u0646 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 SOD1 \u0627\u0644\u0645\u062a\u062d\u0648\u0644\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u062a\u0635\u0644\u0628 \u0627\u0644\u062c\u0627\u0646\u0628\u064a \u0627\u0644\u0636\u0645\u0648\u0631\u064aG93A<\/sup> \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062d\u0633\u0627\u0633\u064a\u0629 \u0645\u0644\u062d\u0648\u0638\u0629. \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0639\u0637\u0644\u0629 Tdp1 \u062a\u062a\u0637\u0648\u0631 \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a\u060c \u0641\u0625\u0646 \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 SOD1G93A<\/sup> \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0644\u0641\u062a\u0643 \u0627\u0644\u062c\u0646\u064a\u0646\u064a \u0627\u0644\u0645\u0628\u0643\u0631. \u0645\u0639\u064b\u0627\u060c \u062a\u0638\u0647\u0631 \u0628\u064a\u0627\u0646\u0627\u062a\u0646\u0627 \u0623\u0646 TDP1 \u064a\u062d\u0644 mtPDBs\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u0646\u0638\u0645 \u0646\u0633\u062e \u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u0648\u0627\u0633\u062a\u0647\u0644\u0627\u0643 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0633\u0641\u0631\u0629 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0629\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u0645\u0646\u062d \u0627\u0644\u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0636\u062f \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a\u0629.<\/p>\n\n\n\n

\u062a\u0634\u064a\u0627\u0646\u063a \u0625\u0633 \u0633\u064a\u060c \u0645\u064a\u062c\u0631 \u0625\u0645\u060c \u0643\u0627\u0633\u0648\u0641 \u0625\u0646\u060c \u062d\u0627\u0641\u0638\u0628\u0627\u0631\u0627\u0633\u062a \u0625\u0645\u060c \u0645\u0627\u0643\u064a\u0646\u0648\u0646 \u0628\u064a \u062c\u064a\u0647\u060c \u0647\u0627\u064a\u0648\u0648\u062f \u0622\u0631\u060c \u0625\u0644-\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633\u0627\u062f\u0633. (2017). \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u064a\u0643\u0633\u0631 \u0646\u0633\u062e \u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u0648\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u062c\u0630\u0648\u0631 \u0627\u0644\u062d\u0631\u0629.<\/a> \u062a\u0642\u062f\u0645 \u0627\u0644\u0639\u0644\u0648\u0645. 3(4):e1602506.<\/p>","protected":false},"excerpt":{"rendered":"

Breakage of one strand of DNA is the most common form of DNA damage. Most damaged DNA termini require end-processing in preparation for ligation. The importance of this step is highlighted by the association of defects in the 3′-end processing enzyme tyrosyl DNA phosphodiesterase 1 (TDP1) and neurodegeneration and by the cytotoxic induction of protein-linked […]<\/p>\n","protected":false},"author":8,"featured_media":369,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[23,61,95],"class_list":{"0":"post-226","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-23","10":"tag-health","11":"tag-research"},"yoast_head":"\nMitochondrial Protein-Linked DNA Breaks Perturb Mitochondrial Gene Transcription and Trigger Free Radical-Induced DNA Damage - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/mitochondrial-protein-linked-dna-breaks-perturb-mitochondrial-gene-transcription-and-trigger-free-radical-induced-dna-damage\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mitochondrial Protein-Linked DNA Breaks Perturb Mitochondrial Gene Transcription and Trigger Free Radical-Induced DNA Damage - Menarah\" \/>\n<meta property=\"og:description\" content=\"Breakage of one strand of DNA is the most common form of DNA damage. Most damaged DNA termini require end-processing in preparation for ligation. 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