{"id":217,"date":"2016-06-11T11:06:26","date_gmt":"2016-06-11T11:06:26","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=217"},"modified":"2024-01-08T10:00:17","modified_gmt":"2024-01-08T10:00:17","slug":"epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\/","title":{"rendered":"\u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0644\u0627\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0623\u0633\u062a\u0644\u0629 \u0647\u064a\u0633\u062a\u0648\u0646 \u062a\u062f\u0639\u0645 \u0645\u0642\u0627\u0648\u0645\u0629 \u0645\u062b\u0628\u0637 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u0623\u0648\u0644 \u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646"},"content":{"rendered":"

\u064a\u0624\u062f\u064a \u0645\u062b\u0628\u0637 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 I (TOP1) \u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646 \u0625\u0644\u0649 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u062d\u0627\u0635\u0631\u0629 TOP1 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0648\u0644\u064a\u062f \u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 (PDBs). \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u062a\u0637\u0628\u064a\u0642\u0647 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 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\u0647\u064a\u0633\u062a\u0648\u0646 H4K16 \u0627\u0644\u0645\u0636\u0637\u0631\u0628\u0629. \u064a\u0645\u0643\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0644\u0627\u062d\u0642 \u0644\u062e\u0644\u0627\u064a\u0627 CRC \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646\u060c \u0648\u0644\u0643\u0646 \u0644\u064a\u0633 \u0627\u0644\u0623\u0628\u0648\u064a\u0629\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062b\u0628\u0637\u0627\u062a \u0647\u064a\u0633\u062a\u0648\u0646 \u062f\u064a\u0627\u0633\u064a\u062a\u064a\u0644\u0627\u0632 (HDAC) \u0623\u0646 \u064a\u062a\u063a\u0644\u0628 \u0639\u0644\u0649 \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0628\u0634\u0643\u0644 \u0641\u0639\u0627\u0644. \u062a\u0624\u0643\u062f \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 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\u0645\u0627\u064a\u0633\u0646\u0628\u064a\u0631\u062c \u0633\u064a\u060c \u0639\u0627\u0634\u0648\u0631 \u0645\u064a\u060c .... \u062f\u0627\u0648\u0646\u0632 JA, Ward SE, El-\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633\u0627\u062f\u0633. (2016). \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0644\u0627\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0623\u0633\u062a\u0644\u0629 \u0647\u064a\u0633\u062a\u0648\u0646 \u062a\u062f\u0639\u0645 \u0645\u0642\u0627\u0648\u0645\u0629 \u0645\u062b\u0628\u0637 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u0623\u0648\u0644 \u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646<\/a>. \u0627\u0644\u062f\u0642\u0629 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u0629. 45(3):1159-117<\/p>","protected":false},"excerpt":{"rendered":"

The topoisomerase I (TOP1) inhibitor irinotecan triggers cell death by trapping TOP1 on DNA, generating cytotoxic protein-linked DNA breaks (PDBs). Despite its wide application in a variety of solid tumors, the mechanisms of cancer cell resistance to irinotecan remains poorly understood. Here, we generated col-orectal cancer (CRC) cell models for irinotecan resistance and report that […]<\/p>\n","protected":false},"author":8,"featured_media":386,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[22,61,95],"class_list":{"0":"post-217","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-22","10":"tag-health","11":"tag-research"},"yoast_head":"\nEpigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan - Menarah\" \/>\n<meta property=\"og:description\" content=\"The topoisomerase I (TOP1) inhibitor irinotecan triggers cell death by trapping TOP1 on DNA, generating cytotoxic protein-linked DNA breaks (PDBs). Despite its wide application in a variety of solid tumors, the mechanisms of cancer cell resistance to irinotecan remains poorly understood. Here, we generated col-orectal cancer (CRC) cell models for irinotecan resistance and report that […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/menarah.org\/ar\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\/\" \/>\n<meta property=\"og:site_name\" content=\"Menarah\" \/>\n<meta property=\"article:published_time\" content=\"2016-06-11T11:06:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-08T10:00:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/menarah.org\/wp-content\/uploads\/2020\/06\/Screenshot-2020-06-26-at-14.56.50.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1258\" \/>\n\t<meta property=\"og:image:height\" content=\"946\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Prof. Sherif El-Khamisy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/SEK2016T\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prof. Sherif El-Khamisy\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"\u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u062d\u062f\u0629\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/\"},\"author\":{\"name\":\"Prof. Sherif El-Khamisy\",\"@id\":\"https:\\\/\\\/menarah.org\\\/#\\\/schema\\\/person\\\/02a18a743abdb604f46256ea79fef499\"},\"headline\":\"Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan\",\"datePublished\":\"2016-06-11T11:06:26+00:00\",\"dateModified\":\"2024-01-08T10:00:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/\"},\"wordCount\":218,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/menarah.org\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/Screenshot-2020-06-26-at-14.56.50.png\",\"keywords\":[\"2016\",\"Health\",\"Research\"],\"articleSection\":[\"Learning from the International Experience\",\"Publications\"],\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/\",\"url\":\"https:\\\/\\\/menarah.org\\\/epigenetic-changes-in-histone-acetylation-underpin-resistance-to-the-topoisomerase-i-inhibitor-irinotecan\\\/\",\"name\":\"Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan - 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