{"id":215,"date":"2017-10-27T11:01:30","date_gmt":"2017-10-27T11:01:30","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=215"},"modified":"2024-01-08T09:56:17","modified_gmt":"2024-01-08T09:56:17","slug":"dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\/","title":{"rendered":"\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a \u0641\u064a \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u062e\u0644\u0648\u064a"},"content":{"rendered":"<p>\u064a\u0634\u0645\u0644 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u062a\u062c\u0645\u0639\u0627\u062a \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a\u0629 \u0645\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 \u062a\u0627\u0648. \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a\u060c \u064a\u0645\u064a\u0644 \u0628\u0631\u0648\u062a\u064a\u0646 \u062a\u0627\u0648 \u0627\u0644\u0645\u0641\u0633\u0641\u0631 \u0625\u0644\u0649 \u0627\u0644\u062a\u0631\u0627\u0643\u0645 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 (\u0633\u0648\u0645\u0627) \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u0645\u062d\u0648\u0631\u064a \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0644\u062a\u0627\u0648. \u062a\u062a\u0645\u062b\u0644 \u0627\u0644\u0625\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648 \u0641\u064a \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0645 \u0627\u0644\u0630\u0627\u062a\u064a \u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u062a\u062c\u0645\u0639\u0627\u062a \u062a\u0627\u0648 \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647\u0627. \u0623\u062d\u062f \u0623\u062f\u0648\u0627\u062a \u0627\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0641\u064a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0645 \u0627\u0644\u0630\u0627\u062a\u064a \u0647\u0648 mTOR. \u064a\u0624\u062f\u064a \u062d\u0638\u0631 mTOR \u0625\u0644\u0649 \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0645 \u0627\u0644\u0630\u0627\u062a\u064a. \u0641\u064a \u0627\u0644\u0622\u0648\u0646\u0629 \u0627\u0644\u0623\u062e\u064a\u0631\u0629\u060c \u0623\u0638\u0647\u0631 \u0643\u0634\u0641 \u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0644\u0640 mTOR \u0623\u0646\u0647 \u064a\u062a\u0643\u0648\u0646 \u0645\u0646 \u0648\u062d\u062f\u062a\u064a\u0646 \u0641\u0631\u0639\u064a\u062a\u064a\u0646: mTORC1\/C2. \u0644\u0630\u0627\u060c \u064a\u0628\u062f\u0648 \u062d\u0638\u0631 \u0643\u0644\u062a\u0627 \u0627\u0644\u0648\u062d\u062f\u062a\u064a\u0646 \u0627\u0644\u0641\u0631\u0639\u064a\u062a\u064a\u0646 \u0645\u0646 mTOR \u0623\u0643\u062b\u0631 \u062c\u0627\u0630\u0628\u064a\u0629 \u0644\u0623\u0646\u0647 \u0633\u064a\u0633\u062a\u0643\u0634\u0641 \u062c\u0645\u064a\u0639 \u0642\u062f\u0631\u0627\u062a \u062c\u0632\u064a\u0621 mTOR. \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0642\u0645\u0646\u0627 \u0628\u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0639\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 pp242 \u0648\u0647\u0648 \u0645\u0627\u0646\u0639 \u0645\u0632\u062f\u0648\u062c mTORC1\/C2 \u0641\u064a \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u062e\u0644\u0648\u064a \u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062e\u0637 \u062e\u0644\u0627\u064a\u0627 LUHMES. \u0623\u062f\u062a \u0625\u0636\u0627\u0641\u0629 \u0627\u0644\u0641\u064a\u0646\u0627\u0632\u0627\u0643\u064a\u0646 \u0625\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 LUHMES \u0625\u0644\u0649 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a \u0641\u064a \u0634\u0643\u0644 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0645\u062c\u0627\u0645\u064a\u0639 \u0627\u0644\u0641\u0648\u0633\u0641\u0648 \u062a\u0627\u0648. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0644\u0641\u064a\u0646\u0627\u0632\u0627\u0643\u0648\u064a\u0646 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u062c\u0633\u062f\u064a \u0627\u0644\u0645\u0645\u064a\u0632 \u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u062a\u0627\u0648. \u0623\u062f\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 PP242 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a \u0627\u0644\u062d\u0627\u0644\u064a \u0625\u0644\u0649 \u0639\u0643\u0633 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u062f\u0648\u0646 \u0633\u0645\u064a\u0629 \u062e\u0644\u0648\u064a\u0629 \u0645\u0644\u062d\u0648\u0638\u0629 \u0644\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0627\u0644\u0628\u0627\u0644\u063a\u0629 1000 \u0646\u0627\u0646\u0648\u0645\u062a\u0631. \u062a\u0642\u062a\u0631\u062d \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 pp242 \u0643\u062d\u0627\u062c\u0632 \u0645\u0632\u062f\u0648\u062c \u0644\u0640 mTOR \u0644\u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648\u0648\u0628\u0627\u062b\u064a.<\/p>\n\n\n\n<p><strong>\u0633\u0644\u0627\u0645\u0629<\/strong> \u0645\u060c \u0627\u0644\u062d\u0633\u064a\u0646\u064a \u0645\u060c \u0645\u062c\u062f\u064a \u0623\u060c \u0639\u0645\u0631\u0627\u0646 \u0623\u060c \u0627\u0644\u0633\u064a\u062f \u0623\u060c \u0639\u0634\u0631\u064a \u0623\u060c \u0645\u062d\u0645\u062f \u0648. 2017. <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11011-017-0137-7\">\u0645\u0627\u0646\u0639 mTORC1 \/ mTORC2 \u0627\u0644\u0645\u0632\u062f\u0648\u062c \u0643\u0639\u0644\u0627\u062c \u0645\u062d\u062a\u0645\u0644 \u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062a\u0627\u0648 \u0641\u064a \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u062e\u0644\u0648\u064a<\/a>. \u0645\u064a\u062a\u0627\u0628 \u0628\u0631\u064a\u0646 \u062f\u064a\u0633 33(2)\u060c 583-587.<\/p>","protected":false},"excerpt":{"rendered":"<p>Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. A suggested therapeutic strategy for tauopathy is to induce autophagy to increase the ability to get rid of the unwanted tau [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":351,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[23,61,95],"class_list":{"0":"post-215","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-23","10":"tag-health","11":"tag-research"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Possible therapy for tauopathy in cellular model - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Possible therapy for tauopathy in cellular model - Menarah\" \/>\n<meta property=\"og:description\" content=\"Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. A suggested therapeutic strategy for tauopathy is to induce autophagy to increase the ability to get rid of the unwanted tau [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/menarah.org\/ar\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\/\" \/>\n<meta property=\"og:site_name\" content=\"Menarah\" \/>\n<meta property=\"article:published_time\" content=\"2017-10-27T11:01:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-08T09:56:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/menarah.org\/wp-content\/uploads\/2020\/06\/Screenshot-2020-06-26-at-14.27.01.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1632\" \/>\n\t<meta property=\"og:image:height\" content=\"442\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Dr. Mohamed Salama\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dr. Mohamed Salama\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"\u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u062d\u062f\u0629\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/\"},\"author\":{\"name\":\"Dr. Mohamed Salama\",\"@id\":\"https:\\\/\\\/menarah.org\\\/#\\\/schema\\\/person\\\/31d8b4616fa7455ebb0b07916a647a77\"},\"headline\":\"Possible therapy for tauopathy in cellular model\",\"datePublished\":\"2017-10-27T11:01:30+00:00\",\"dateModified\":\"2024-01-08T09:56:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/\"},\"wordCount\":233,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/menarah.org\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/Screenshot-2020-06-26-at-14.27.01.png\",\"keywords\":[\"2017\",\"Health\",\"Research\"],\"articleSection\":[\"Learning from the International Experience\",\"Publications\"],\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/\",\"url\":\"https:\\\/\\\/menarah.org\\\/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model\\\/\",\"name\":\"Possible therapy for tauopathy in cellular model - 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