{"id":203,"date":"2018-06-01T10:26:27","date_gmt":"2018-06-01T10:26:27","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=203"},"modified":"2024-01-08T09:53:41","modified_gmt":"2024-01-08T09:53:41","slug":"uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\/","title":{"rendered":"\u064a\u0646\u0638\u0645 UCHL3 \u0625\u0635\u0644\u0627\u062d \u0643\u0633\u0631 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632"},"content":{"rendered":"

\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062a\u0645\u064a\u0632 \u0627\u0644\u0636\u0631\u0631 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0628\u0648\u062c\u0648\u062f \u0631\u0648\u0627\u0628\u0637 \u0645\u062a\u0642\u0627\u0637\u0639\u0629 \u0628\u064a\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u062d\u064a\u062b \u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0631\u0627\u0643\u0645\u0647\u0627 \u0627\u0644\u062d\u0627\u062f \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u064a\u0624\u062f\u064a \u0627\u0644\u062a\u0631\u0627\u0643\u0645 \u0627\u0644\u062a\u062f\u0631\u064a\u062c\u064a \u0625\u0644\u0649 \u062a\u0646\u0643\u0633 \u0639\u0635\u0628\u064a. \u0648\u064a\u062a\u0645\u062b\u0644 \u0630\u0644\u0643 \u0641\u064a \u0625\u0646\u0632\u064a\u0645 Tyrosyl DNA phosphodiesterase 1 (TDP1)\u060c \u0627\u0644\u0630\u064a \u064a\u0639\u0645\u0644 \u0639\u0644\u0649 \u0625\u0635\u0644\u0627\u062d \u0641\u0648\u0627\u0635\u0644 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u062a\u064a \u064a\u062a\u0648\u0633\u0637\u0647\u0627 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a TDP1 \u062a\u062e\u062a\u0644\u0641 \u0641\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0625\u0639\u062f\u0627\u062f\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u0622\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0642\u0648\u0645 \u0639\u0644\u064a\u0647\u0627 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641\u0629. \u0646\u0643\u0634\u0641 \u0623\u0646 TDP1 \u064a\u062a\u0645 \u0627\u0644\u062a\u062d\u0643\u0645 \u0641\u064a\u0647 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0641\u064a \u0643\u0644 \u0645\u0643\u0627\u0646 \u0648\u0646\u062d\u062f\u062f UCHL3 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u062f\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0644\u064a\u0632 \u0627\u0644\u0630\u064a \u064a\u062a\u062d\u0643\u0645 \u0641\u064a \u062b\u0628\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a TDP1. \u064a\u0624\u062f\u064a \u0627\u0633\u062a\u0646\u0641\u0627\u062f UCHL3 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u0646\u062a\u0634\u0627\u0631 TDP1 \u0648\u0645\u0639\u062f\u0644 \u062f\u0648\u0631\u0627\u0646\u0647 \u0648\u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0633\u0645\u0648\u0645 TOP1. \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 UCHL3\u060c \u0648\u0644\u0643\u0646 \u0644\u064a\u0633 \u0645\u062a\u062d\u0648\u0644\u0629 \u063a\u064a\u0631 \u0646\u0634\u0637\u0629 \u062a\u062d\u0641\u064a\u0632\u064a\u064b\u0627\u060c \u064a\u0645\u0646\u0639 \u0627\u0646\u062a\u0634\u0627\u0631 TDP1 \u0648\u0645\u0639\u062f\u0644 \u062f\u0648\u0631\u0627\u0646\u0647. \u0625\u0646 \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 TDP1 \u0641\u064a \u0633\u0627\u0631\u0643\u0648\u0645\u0629 \u0627\u0644\u0639\u0636\u0644\u0629 \u0627\u0644\u0645\u062e\u0637\u0637\u0629 \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 \u0647\u0648 \u0627\u0644\u062f\u0627\u0641\u0639 \u0648\u0631\u0627\u0621 \u0627\u0644\u0625\u0641\u0631\u0627\u0637 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 UCHL3. \u0639\u0644\u0649 \u0627\u0644\u0646\u0642\u064a\u0636 \u0645\u0646 \u0630\u0644\u0643\u060c \u064a\u062a\u0645 \u062a\u0646\u0638\u064a\u0645 UCHL3 \u0641\u064a \u0627\u0644\u0631\u0646\u062d \u0627\u0644\u0645\u062e\u064a\u062e\u064a \u0627\u0644\u0634\u0648\u0643\u064a \u0645\u0639 \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u062d\u0648\u0631\u064a (SCAN1)\u060c \u0645\u0645\u0627 \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0646 \u0627\u0646\u062a\u0634\u0627\u0631 TDP1 \u0641\u064a \u0643\u0644 \u0645\u0643\u0627\u0646 \u0648\u0645\u0639\u062f\u0644 \u062f\u0648\u0631\u0627\u0646 \u0623\u0633\u0631\u0639. \u062a\u062d\u062f\u062f \u0647\u0630\u0647 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a UCHL3 \u0643\u0645\u0646\u0638\u0645 \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a TDP1\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c \u0645\u0648\u0627\u0644\u0641 \u062f\u0642\u064a\u0642 \u0644\u0625\u0635\u0644\u0627\u062d \u0643\u0633\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u0644\u064a\u0627\u0648 \u0633\u064a\u060c \u2026\u2026\u060c \u062f\u064a\u0643\u0645\u0627\u0646 \u0625\u0645 \u062c\u064a\u060c \u0625\u0644-\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633\u0627\u062f\u0633 (2018). \u064a\u0646\u0638\u0645 UCHL3 \u0625\u0635\u0644\u0627\u062d \u0643\u0633\u0631 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062a\u062d\u0643\u0645 \u0641\u064a \u062b\u0628\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a TDP1<\/a>. \u062a\u0642\u0627\u0631\u064a\u0631 \u0627\u0644\u062e\u0644\u064a\u0629\u060c 23\u060c 3352-3365<\/p>","protected":false},"excerpt":{"rendered":"

Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration. This is typified by tyrosyl DNA phosphodiesterase 1 (TDP1), which repairs topoisomerase-mediated chromosomal breaks. Although TDP1 levels vary in multiple clinical settings, the mechanism underpinning this variation is unknown. We reveal that TDP1 is controlled […]<\/p>\n","protected":false},"author":8,"featured_media":335,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[24,61,95],"class_list":{"0":"post-203","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-24","10":"tag-health","11":"tag-research"},"yoast_head":"\nUCHL3 regulates topoisomerase induced chromosomal break repair - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UCHL3 regulates topoisomerase induced chromosomal break repair - Menarah\" \/>\n<meta property=\"og:description\" content=\"Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration. This is typified by tyrosyl DNA phosphodiesterase 1 (TDP1), which repairs topoisomerase-mediated chromosomal breaks. Although TDP1 levels vary in multiple clinical settings, the mechanism underpinning this variation is unknown. We reveal that TDP1 is controlled […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/menarah.org\/ar\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\/\" \/>\n<meta property=\"og:site_name\" content=\"Menarah\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-01T10:26:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-08T09:53:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/menarah.org\/wp-content\/uploads\/2020\/06\/Screenshot-2020-06-26-at-14.08.21.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1342\" \/>\n\t<meta property=\"og:image:height\" content=\"1336\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Prof. Sherif El-Khamisy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/SEK2016T\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prof. Sherif El-Khamisy\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"\u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u062d\u062f\u0629\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/\"},\"author\":{\"name\":\"Prof. Sherif El-Khamisy\",\"@id\":\"https:\\\/\\\/menarah.org\\\/#\\\/schema\\\/person\\\/02a18a743abdb604f46256ea79fef499\"},\"headline\":\"UCHL3 regulates topoisomerase induced chromosomal break repair\",\"datePublished\":\"2018-06-01T10:26:27+00:00\",\"dateModified\":\"2024-01-08T09:53:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/\"},\"wordCount\":175,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/menarah.org\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/Screenshot-2020-06-26-at-14.08.21.png\",\"keywords\":[\"2018\",\"Health\",\"Research\"],\"articleSection\":[\"Learning from the International Experience\",\"Publications\"],\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/\",\"url\":\"https:\\\/\\\/menarah.org\\\/uchl3-regulates-topoisomerase-induced-chromosomal-break-repair-by-controlling-tdp1-proteostasis\\\/\",\"name\":\"UCHL3 regulates topoisomerase induced chromosomal break repair - 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