{"id":197,"date":"2018-11-01T20:16:15","date_gmt":"2018-11-01T20:16:15","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=197"},"modified":"2024-01-08T09:50:46","modified_gmt":"2024-01-08T09:50:46","slug":"foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\/","title":{"rendered":"\u0625\u0633\u0643\u0627\u062a FOXRED1 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646: \u0646\u0645\u0648\u0630\u062c \u062d\u064a\u0648\u0627\u0646\u064a \u0645\u062d\u062a\u0645\u0644 \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0647"},"content":{"rendered":"<p>\u062a\u0639\u062f \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a (LS) \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u0627\u0644\u0623\u0643\u062b\u0631 \u0625\u062b\u0627\u0631\u0629 \u0644\u0644\u062d\u064a\u0631\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u064f\u0639\u0631\u0641 \u0623\u064a\u0636\u064b\u0627 \u0628\u0627\u0633\u0645 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u062f\u0645\u0627\u063a \u0627\u0644\u0646\u0627\u062e\u0631 \u062a\u062d\u062a \u0627\u0644\u062d\u0627\u062f. \u064a\u0628\u0644\u063a \u0645\u0639\u062f\u0644 \u062d\u062f\u0648\u062b\u0647 1 \u0645\u0646 \u0643\u0644 77000 \u0648\u0644\u0627\u062f\u0629 \u062d\u064a\u0629 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645 \u0645\u0639 \u0633\u0648\u0621 \u0627\u0644\u062a\u0634\u062e\u064a\u0635. \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u060c \u0647\u0646\u0627\u0643 \u0641\u0647\u0645 \u0636\u0639\u064a\u0641 \u0644\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u0645\u0631\u0636 \u062f\u0648\u0646 \u0623\u064a \u0639\u0644\u0627\u062c \u0641\u0639\u0627\u0644 \u0645\u062a\u0627\u062d. \u0648\u0645\u0646 \u062b\u0645\u060c \u0641\u0625\u0646 \u062d\u062a\u0645\u064a\u0629 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629 \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u062a\u0637\u0648\u064a\u0631 \u0637\u0631\u0627\u0626\u0642 \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0646\u0627\u062c\u062d\u0629. \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u0642\u0635\u064a\u0631\u060c \u0642\u0645\u0646\u0627 \u0628\u062d\u0638\u0631 \u062c\u064a\u0646 FOXRED1 \u0627\u0644\u0630\u064a \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 RNA \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644 \u0627\u0644\u0635\u063a\u064a\u0631 (siRNA) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 C57bl\/6. \u0648\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u062a\u063a\u064a\u0631\u0627\u062a \u0633\u0644\u0648\u0643\u064a\u0629 \u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u062d\u0642\u0648\u0646\u0629 \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0627\u0646\u062d\u0637\u0627\u0637 \u0645\u0648\u0627\u0632 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u062e\u0637\u0637 \u0648\u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0633\u0648\u062f\u0627\u0621 \u0639\u0644\u0649 \u063a\u0631\u0627\u0631 \u0645\u0627 \u064a\u062d\u062f\u062b \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a. \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0627\u0646\u0633\u062f\u0627\u062f FOXRED1 \u0628\u0645\u062b\u0627\u0628\u0629 \u0646\u0645\u0648\u0630\u062c \u062d\u064a\u0648\u0627\u0646\u064a \u062c\u062f\u064a\u062f \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0647 \u0628\u0633\u0628\u0628 \u062e\u0644\u0644 \u0641\u064a CI\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0639\u0643\u0633 \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u062a\u064a \u0644\u062d\u0642\u062a \u0628\u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u062e\u0637\u0637 \u0648\u062a\u0623\u062b\u0631 \u0646\u0638\u0627\u0645 \u0627\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636. \u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0635\u062d\u0629 \u0647\u0630\u0627 \u0627\u0644\u0646\u0645\u0648\u0630\u062c.<\/p>\n\n\n\n<p><strong>\u0633\u0644\u0627\u0645\u0629<\/strong> \u0645\u060c \u0627\u0644\u062f\u0633\u0648\u0642\u064a \u0633\u060c \u0627\u0644\u0633\u064a\u062f \u0623\u060c \u0627\u0644\u062d\u0633\u064a\u0646\u064a \u0645\u060c \u0645\u0635\u0637\u0641\u0649 \u0623\u060c \u0637\u0644\u0628 \u064a.\u060c \u0645\u062d\u0645\u062f \u0648. (2018)&nbsp;<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11011-018-0334-z\">\u0625\u0633\u0643\u0627\u062a FOXRED1 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646: \u0646\u0645\u0648\u0630\u062c \u062d\u064a\u0648\u0627\u0646\u064a \u0645\u062d\u062a\u0645\u0644 \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0647<\/a>. \u0645\u062a\u0639\u0628 \u0627\u0644\u062f\u0645\u0627\u063a<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>\u062d\u0642\u0648\u0642 \u0627\u0644\u0635\u0648\u0631\u0629: \u0631\u0648\u0628\u064a\u0646\u0627 \u0648\u064a\u0631\u0645\u064a\u062c\u0631 \u2013 unsplash.com<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Leigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understanding of the underlying pathophysiological mechanisms of the disease without any available effective treatment. Hence, the inevitability [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":684,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[24,61,95],"class_list":{"0":"post-197","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-24","10":"tag-health","11":"tag-research"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>FOXRED1 silencing in mice: A possible animal model for Leigh Syndrome - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FOXRED1 silencing in mice: A possible animal model for Leigh Syndrome - Menarah\" \/>\n<meta property=\"og:description\" content=\"Leigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understanding of the underlying pathophysiological mechanisms of the disease without any available effective treatment. Hence, the inevitability [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/menarah.org\/ar\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"Menarah\" \/>\n<meta property=\"article:published_time\" content=\"2018-11-01T20:16:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-08T09:50:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/menarah.org\/wp-content\/uploads\/2018\/11\/robina-weermeijer-igwG8aIaypo-unsplash-scaled-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Dr. Mohamed Salama\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dr. Mohamed Salama\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"\u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u062d\u062f\u0629\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/\"},\"author\":{\"name\":\"Dr. Mohamed Salama\",\"@id\":\"https:\\\/\\\/menarah.org\\\/#\\\/schema\\\/person\\\/31d8b4616fa7455ebb0b07916a647a77\"},\"headline\":\"FOXRED1 silencing in mice: A possible animal model for Leigh Syndrome\",\"datePublished\":\"2018-11-01T20:16:15+00:00\",\"dateModified\":\"2024-01-08T09:50:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/\"},\"wordCount\":203,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/menarah.org\\\/wp-content\\\/uploads\\\/2018\\\/11\\\/robina-weermeijer-igwG8aIaypo-unsplash-scaled-1.jpg\",\"keywords\":[\"2018\",\"Health\",\"Research\"],\"articleSection\":[\"Learning from the International Experience\",\"Publications\"],\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/\",\"url\":\"https:\\\/\\\/menarah.org\\\/foxred1-silencing-in-mice-a-possible-animal-model-for-leigh-syndrome\\\/\",\"name\":\"FOXRED1 silencing in mice: A possible animal model for Leigh Syndrome - 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