{"id":188,"date":"2019-09-01T19:43:32","date_gmt":"2019-09-01T19:43:32","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=188"},"modified":"2024-01-08T09:46:43","modified_gmt":"2024-01-08T09:46:43","slug":"a-novel-dna-damage-response-to-replicative-stress-by-the-typhoid-toxin-facilitates-cellular-senescence-and-salmonella-infection","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/a-novel-dna-damage-response-to-replicative-stress-by-the-typhoid-toxin-facilitates-cellular-senescence-and-salmonella-infection\/","title":{"rendered":"\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0643\u0631\u0627\u0631\u064a"},"content":{"rendered":"

\u0627\u0644\u0633\u0627\u0644\u0645\u0648\u0646\u064a\u0644\u0627<\/em> \u064a\u0646\u0634\u0637 \u0627\u0644\u062a\u064a\u0641\u064a \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0636\u064a\u0641 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0633\u0645\u0648\u0645 \u0627\u0644\u062a\u064a\u0641\u0648\u0626\u064a\u062f\u060c \u0645\u0645\u0627 \u064a\u0633\u0647\u0644 \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062a\u064a\u0641\u0648\u0626\u064a\u062f \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0632\u0645\u0646\u0629. \u0646\u0643\u0634\u0641 \u0647\u0646\u0627 \u0639\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u063a\u064a\u0631 \u0642\u0627\u0646\u0648\u0646\u064a\u0629 \u0644\u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0648\u0627\u0644\u062a\u064a \u0646\u0633\u0645\u064a\u0647\u0627 RING (\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0644\u0633\u0645\u0648\u0645 \u0627\u0644\u062c\u064a\u0646\u064a\u0629)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062a\u0645\u064a\u0632 \u0628\u062a\u0631\u0627\u0643\u0645 \u0647\u064a\u0633\u062a\u0648\u0646 \u0627\u0644\u0645\u0641\u0633\u0641\u0631 H2AX (\u03b3H2AX) \u0641\u064a \u0627\u0644\u0645\u062d\u064a\u0637 \u0627\u0644\u0646\u0648\u0648\u064a. RING \u0647\u0648 \u0646\u062a\u064a\u062c\u0629 \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0633\u062a\u0645\u0631 \u0628\u0648\u0633\u0627\u0637\u0629 \u0646\u0634\u0627\u0637 \u0646\u0648\u0643\u0644\u064a\u0627\u0632 \u0627\u0644\u0633\u0645 \u0648\u064a\u062a\u0645\u064a\u0632 \u0628\u0641\u0631\u0637 \u0627\u0644\u0641\u0633\u0641\u0631\u0629 \u0641\u064a RPA\u060c \u0648\u0647\u0648 \u062c\u0647\u0627\u0632 \u0627\u0633\u062a\u0634\u0639\u0627\u0631 \u0644\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0641\u0631\u062f \u0627\u0644\u0630\u064a \u062a\u0642\u0637\u0639\u062a \u0628\u0647 \u0627\u0644\u0633\u0628\u0644 (ssDNA) \u0648\u0625\u062c\u0647\u0627\u062f \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u064a\u0639\u0645\u0644 \u0627\u0644\u0633\u0645 \u0639\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u062a\u062d\u0645\u064a\u0644 \u0645\u0633\u0627\u0631 RPA \u0628\u0631\u0643\u064a\u0632\u0629 ssDNA\u060c \u0645\u0645\u0627 \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u0627\u0633\u062a\u0646\u0641\u0627\u062f RPA \u0648\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629. \u064a\u062a\u0645 \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0623\u064a\u0636\u064b\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0628\u0624\u0631 \u03b3\u03972\u0391\u03a7 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0643\u0634\u0641 \u0639\u0646 \u0622\u0644\u064a\u0627\u062a \u0645\u062a\u0645\u064a\u0632\u0629. \u064a\u0646\u062a\u0642\u0644 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0625\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0627\u0631\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062e\u0645\u0648\u0631\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0639\u0627\u0645\u0644 \u0625\u0641\u0631\u0627\u0632\u064a \u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0645\u062c\u0647\u0648\u0644 \u0627\u0644\u0647\u0648\u064a\u0629 \u064a\u0639\u0632\u0632 \u0627\u0644\u0633\u0627\u0644\u0645\u0648\u0646\u064a\u0644\u0627<\/em> \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a. \u0648\u0647\u0643\u0630\u0627 \u064a\u0643\u0634\u0641 \u0639\u0645\u0644\u0646\u0627 \u0639\u0646 \u0622\u0644\u064a\u0629 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0633\u0627\u0644\u0645\u0648\u0646\u064a\u0644\u0627<\/em> \u064a\u0633\u062a\u0646\u0632\u0641 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 RPA \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062d\u0641\u064a\u0632 \u062a\u0643\u0648\u064a\u0646 ssDNA\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0636\u064a\u0641\u0629 \u0648\u062a\u0633\u0647\u064a\u0644 \u0627\u0644\u0639\u062f\u0648\u0649.<\/p>\n\n\n\n

\u0625\u0628\u0644\u0631 \u0623\u060c \u0628\u0648\u0644\u062c\u0627\u0643\u0648\u0641\u0627 \u0646\u060c \u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633\u0627\u062f\u0633\u060c \u0647\u0645\u0641\u0631\u064a\u0632 \u062f (2019). \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0643\u0631\u0627\u0631\u064a \u0628\u0648\u0627\u0633\u0637\u0629 \u0633\u0645\u0648\u0645 \u0627\u0644\u062a\u064a\u0641\u0648\u0626\u064a\u062f \u062a\u0633\u0647\u0644 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0648\u0639\u062f\u0648\u0649 \u0627\u0644\u0633\u0627\u0644\u0645\u0648\u0646\u064a\u0644\u0627<\/a>. \u0627\u062a\u0635\u0627\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0639\u0629\u060c 10: 4040<\/p>","protected":false},"excerpt":{"rendered":"

Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by a genotoxin), characterized by accumulation of phosphorylated histone H2AX (\u03b3H2AX) at the nuclear periphery. RING is the result of persistent DNA damage mediated […]<\/p>\n","protected":false},"author":8,"featured_media":430,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[25,33,61,95],"class_list":{"0":"post-188","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-25","10":"tag-ageing","11":"tag-health","12":"tag-research"},"yoast_head":"\nA novel DNA damage response to replicative stress - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/a-novel-dna-damage-response-to-replicative-stress-by-the-typhoid-toxin-facilitates-cellular-senescence-and-salmonella-infection\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A novel DNA damage response to replicative stress - Menarah\" \/>\n<meta property=\"og:description\" content=\"Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by a genotoxin), characterized by accumulation of phosphorylated histone H2AX (\u03b3H2AX) at the nuclear periphery. 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