{"id":183,"date":"2020-03-01T19:00:00","date_gmt":"2020-03-01T19:00:00","guid":{"rendered":"https:\/\/www-menarah-org.kentuniresestg.wpengine.com\/?p=183"},"modified":"2024-01-08T09:44:27","modified_gmt":"2024-01-08T09:44:27","slug":"tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts","status":"publish","type":"post","link":"https:\/\/menarah.org\/ar\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\/","title":{"rendered":"\u064a\u0646\u0633\u0642 TEX264 \u062f\u0642\u0629 p97 \u0648 SPRTN \u0644\u0645\u0642\u0627\u0631\u0628\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 1."},"content":{"rendered":"<p>\u064a\u0646\u0638\u0645 \u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 \u062d\u0642\u064a\u0642\u064a \u0627\u0644\u0646\u0648\u0627\u0629 1 (TOP1) \u0637\u0648\u0628\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0636\u0645\u0627\u0646 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0648\u0646\u0633\u062e\u0647 \u0628\u0643\u0641\u0627\u0621\u0629. \u064a\u0639\u062f TOP1 \u0623\u064a\u0636\u064b\u0627 \u0645\u062d\u0631\u0643\u064b\u0627 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0644\u0639\u062f\u0645 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u062f\u0627\u062e\u0644\u064a\u060c \u062e\u0627\u0635\u0629 \u0639\u0646\u062f\u0645\u0627 \u064a\u0633\u062a\u0642\u0631 \u0648\u0633\u064a\u0637\u0647 \u0627\u0644\u062a\u062d\u0641\u064a\u0632\u064a - \u0648\u0647\u0648 \u0645\u0631\u0643\u0628 \u062a\u0633\u0627\u0647\u0645\u064a TOP1-DNA \u064a\u064f\u0639\u0631\u0641 \u0628\u0627\u0633\u0645 \u0645\u062c\u0645\u0639 \u0627\u0644\u0627\u0646\u0642\u0633\u0627\u0645 TOP1 (TOP1cc). \u062a\u0639\u062a\u0628\u0631 TOP1ccs \u0634\u062f\u064a\u062f\u0629 \u0627\u0644\u0633\u0645\u064a\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0641\u0634\u0644 \u0641\u064a \u062d\u0644\u0647\u0627 \u064a\u0643\u0645\u0646 \u0648\u0631\u0627\u0621 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0648\u0644\u0643\u0646 \u064a\u062a\u0645 \u0627\u0633\u062a\u063a\u0644\u0627\u0644\u0647\u0627 \u0623\u064a\u0636\u064b\u0627 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u062d\u064a\u062b \u064a\u0643\u0648\u0646 TOP1ccs \u0647\u062f\u0641\u064b\u0627 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0641\u064a \u0627\u0644\u062e\u0637\u0648\u0637 \u0627\u0644\u0623\u0645\u0627\u0645\u064a\u0629. \u0625\u0646 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u062d\u0627\u0633\u0645 \u0644\u062a\u062d\u0644\u064a\u0644 TOP1cc \u0647\u0648 \u0625\u0646\u0632\u064a\u0645 Tyrosyl-DNA phosphodiesterase (TDP1)\u060c \u0627\u0644\u0630\u064a \u064a\u062d\u0644\u0644 \u0627\u0644\u0631\u0627\u0628\u0637\u0629 \u0627\u0644\u062a\u064a \u062a\u0631\u0628\u0637 \u0627\u0644\u062a\u064a\u0631\u0648\u0632\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u0646\u0634\u0637 \u0644\u0640 TOP1 \u0628\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u0648\u0633\u0641\u0627\u062a 3&#039; \u0639\u0644\u0649 \u0643\u0633\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0641\u0631\u062f \u0627\u0644\u0630\u064a \u062a\u0642\u0637\u0639\u062a \u0628\u0647 \u0627\u0644\u0633\u0628\u0644. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u064a\u0645\u0643\u0646 \u0644\u0640 TDP1 \u0641\u0642\u0637 \u0645\u0639\u0627\u0644\u062c\u0629 \u0634\u0638\u0627\u064a\u0627 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0645\u0646 \u0646\u0647\u0627\u064a\u0627\u062a ssDNA\u060c \u0645\u0645\u0627 \u064a\u062b\u064a\u0631 \u0627\u0644\u062a\u0633\u0627\u0624\u0644 \u062d\u0648\u0644 \u0643\u064a\u0641\u064a\u0629 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 ~ 90 \u0643\u064a\u0644\u0648 \u062f\u0627\u0644\u062a\u0648\u0646 TOP1 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u0627 \u0642\u0628\u0644 TDP1. \u0647\u0646\u0627 \u0646\u062c\u062f \u0623\u0646 TEX264 \u064a\u0624\u062f\u064a \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0631 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0643\u0648\u064a\u0646 \u0645\u0631\u0643\u0628 \u0645\u0639 p97 ATPase \u0648SPRTN metalloprotease. \u0646\u0648\u0636\u062d \u0623\u0646 TEX264 \u064a\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0643\u0644 \u0645\u0646 TOP1 \u063a\u064a\u0631 \u0627\u0644\u0645\u0639\u062f\u0644 \u0648\u0627\u0644\u0645\u0639\u062f\u0644 \u0628\u0640 SUMO1 \u0648\u064a\u0628\u062f\u0623 \u0625\u0635\u0644\u0627\u062d TOP1cc \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062c\u0646\u064a\u062f p97 \u0648SPRTN. \u064a\u062a\u0645\u0631\u0643\u0632 TEX264 \u0641\u064a \u0627\u0644\u0645\u062d\u064a\u0637 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0648\u064a\u0631\u062a\u0628\u0637 \u0628\u0634\u0648\u0643\u0627\u062a \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0648\u064a\u062a\u0635\u062f\u0649 \u0644\u0640 TOP1ccs \u0623\u062b\u0646\u0627\u0621 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u0628\u0634\u0643\u0644 \u0639\u0627\u0645\u060c \u062a\u0648\u0636\u062d \u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u0648\u062c\u0648\u062f \u0645\u062c\u0645\u0639 \u0625\u0635\u0644\u0627\u062d \u0645\u062a\u062e\u0635\u0635 \u0645\u0637\u0644\u0648\u0628 \u0644\u0644\u062a\u062d\u0644\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a \u0627\u0644\u0623\u0648\u0644\u064a \u0644\u0640 TOP1ccs \u0648\u062d\u0644\u0647\u0627 \u0627\u0644\u0644\u0627\u062d\u0642.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u0641\u064a\u0644\u062f\u0646 \u062c\u064a\u060c \u0648\u0627\u064a\u0632\u0645\u0627\u0646 \u0643\u060c \u062a\u0648\u0631\u064a\u0633\u064a\u0644\u0627 \u0627\u0644\u0623\u0648\u0644\u060c ............ <strong>\u0627\u0644\u062e\u0645\u064a\u0633\u064a<\/strong> \u0633.\u0641\u060c \u0631\u0645\u0636\u0627\u0646 \u0643 (2020). <a href=\"https:\/\/www.nature.com\/articles\/s41467-020-15000-w\">\u064a\u0646\u0633\u0642 TEX264 \u062f\u0642\u0629 p97 \u0648 SPRTN \u0644\u0645\u0642\u0627\u0631\u0628\u0627\u062a \u0627\u0644\u062a\u0648\u0628\u0648\u064a\u0632\u0648\u0645\u064a\u0631\u0627\u0632 1-DNA<\/a>. <em>\u0627\u062a\u0635\u0627\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0639\u0629<\/em>.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>\u062d\u0642\u0648\u0642 \u0627\u0644\u0635\u0648\u0631\u0629: \u0623\u0644\u0643\u0633\u0646\u062f\u0631 \u0628\u0648\u0641\u0648\u0641-unsplash.com<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate\u2014a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)\u2014is stabilised. TOP1ccs are highly cytotoxic and a failure to resolve them underlies the pathology of neurological [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":695,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[26,61,95],"class_list":{"0":"post-183","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international_learning","8":"category-publications","9":"tag-26","10":"tag-health","11":"tag-research"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. - Menarah<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/menarah.org\/ar\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. - Menarah\" \/>\n<meta property=\"og:description\" content=\"Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate\u2014a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)\u2014is stabilised. TOP1ccs are highly cytotoxic and a failure to resolve them underlies the pathology of neurological [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/menarah.org\/ar\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\/\" \/>\n<meta property=\"og:site_name\" content=\"Menarah\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-01T19:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-08T09:44:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/menarah.org\/wp-content\/uploads\/2020\/03\/alexander-popov-eXoXJrOGqG4-unsplash-scaled-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1707\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Prof. Sherif El-Khamisy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/SEK2016T\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prof. Sherif El-Khamisy\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"\u062f\u0642\u064a\u0642\u062a\u0627\u0646\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/\"},\"author\":{\"name\":\"Prof. Sherif El-Khamisy\",\"@id\":\"https:\\\/\\\/menarah.org\\\/#\\\/schema\\\/person\\\/02a18a743abdb604f46256ea79fef499\"},\"headline\":\"TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.\",\"datePublished\":\"2020-03-01T19:00:00+00:00\",\"dateModified\":\"2024-01-08T09:44:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/\"},\"wordCount\":261,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/menarah.org\\\/wp-content\\\/uploads\\\/2020\\\/03\\\/alexander-popov-eXoXJrOGqG4-unsplash-scaled-1.jpg\",\"keywords\":[\"2020\",\"Health\",\"Research\"],\"articleSection\":[\"Learning from the International Experience\",\"Publications\"],\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/\",\"url\":\"https:\\\/\\\/menarah.org\\\/tex264-coordinates-p97-and-sprtn-mediated-resolution-of-topoisomerase-1-dna-adducts\\\/\",\"name\":\"TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. - 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