{"version":"1.0","provider_name":"\u0645\u0646\u0627\u0631\u0629","provider_url":"https:\/\/menarah.org\/ar","title":"C9orf72 expansion disrupts ATM-mediated chromosomal break repair - Menarah","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"qv90uEIOSd\"><a href=\"https:\/\/menarah.org\/ar\/c9orf72-expansion-disrupts-atm-mediated-chromosomal-break-repair\/\">\u064a\u0624\u062f\u064a \u062a\u0648\u0633\u064a\u0639 C9orf72 \u0625\u0644\u0649 \u062a\u0639\u0637\u064a\u0644 \u0625\u0635\u0644\u0627\u062d \u0643\u0633\u0631 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0628\u0648\u0633\u0627\u0637\u0629 \u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u0635\u0631\u0627\u0641 \u0627\u0644\u0622\u0644\u064a<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/menarah.org\/ar\/c9orf72-expansion-disrupts-atm-mediated-chromosomal-break-repair\/embed\/#?secret=qv90uEIOSd\" width=\"600\" height=\"338\" title=\"\u201c&quot;\u062a\u0648\u0633\u0639 \u062c\u064a\u0646 C9orf72 \u064a\u0639\u0637\u0644 \u0639\u0645\u0644\u064a\u0629 \u0625\u0635\u0644\u0627\u062d \u0627\u0646\u0642\u0637\u0627\u0639\u0627\u062a \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0628\u0648\u0633\u0627\u0637\u0629 ATM&quot; - \u0645\u0646\u0627\u0631\u0629\" data-secret=\"qv90uEIOSd\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/* ]]> *\/\n<\/script>","thumbnail_url":"https:\/\/menarah.org\/wp-content\/uploads\/2017\/07\/6.png","thumbnail_width":300,"thumbnail_height":398,"description":"Hexanucleotide repeat expansions represent the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, though the mechanisms by which such expansions cause neurodegeneration are poorly understood. We report elevated levels of DNA\u2013RNA hybrids (R-loops) and double strand breaks in rat neurons, human cells and&nbsp;C9orf72&nbsp;ALS patient spinal cord tissues. Accumulation of endogenous DNA [&hellip;]"}